KI-7

Research use only, not for human use.

KI-7 is an adenosine A2B receptor positive allosteric modulator.

KI-7 is an adenosine A2B receptor positive allosteric modulator.

KI-7 (1 μM; 5-21 days; mesenchymal stem cells) induces a significant increase in mRNA expression of Runx2 and Osterix.KI-7 (1 μM; 15-21 days) induced a significant increase in cell viability in both differentiation stages.KI-7, as A2B adenosine receptor positive allosteric modulator in MSCs, demonstrating it is able to potentiate the effects of either adenosine and synthetic orthosteric A2B adenosine receptor agonists in mediating osteoblast differentiation in vitro. NECA, BAY 60-6583 and KI-7 induce a strong increase in IL-6 production. KI-7 is able to potentiate the effects of orthosteric agonists in both differentiation stages, even if the effect became significant only at 21 days.

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Apoptosis

Adenosine Receptor

A2B

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1489263-00-4

354.4

C23H18N2O2

>98% (HPLC)

DMSO:240 mg/mL?(677.20 mM;?Need ultrasonic)

O=C(C(Nc1ccccc1)=O)c1cn(Cc2ccccc2)c2c1cccc2

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(-20℃)

With Ice Pack

≥ 2 years