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KI-7
CAS No. 1489263-00-4
KI-7( —— )
Catalog No. M23641 CAS No. 1489263-00-4
KI-7 is an adenosine A2B receptor positive allosteric modulator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 80 | In Stock |
|
| 10MG | 138 | In Stock |
|
| 25MG | 286 | In Stock |
|
| 50MG | 441 | In Stock |
|
| 100MG | 664 | In Stock |
|
| 500MG | 1377 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKI-7
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NoteResearch use only, not for human use.
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Brief DescriptionKI-7 is an adenosine A2B receptor positive allosteric modulator.
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DescriptionKI-7 is an adenosine A2B receptor positive allosteric modulator.
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In VitroKI-7 (1 μM; 5-21 days; mesenchymal stem cells) induces a significant increase in mRNA expression of Runx2 and Osterix.KI-7 (1 μM; 15-21 days) induced a significant increase in cell viability in both differentiation stages.KI-7, as A2B adenosine receptor positive allosteric modulator in MSCs, demonstrating it is able to potentiate the effects of either adenosine and synthetic orthosteric A2B adenosine receptor agonists in mediating osteoblast differentiation in vitro. NECA, BAY 60-6583 and KI-7 induce a strong increase in IL-6 production. KI-7 is able to potentiate the effects of orthosteric agonists in both differentiation stages, even if the effect became significant only at 21 days.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorA2B
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Research Area——
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Indication——
Chemical Information
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CAS Number1489263-00-4
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Formula Weight354.4
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Molecular FormulaC23H18N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:240 mg/mL?(677.20 mM;?Need ultrasonic)
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SMILESO=C(C(Nc1ccccc1)=O)c1cn(Cc2ccccc2)c2c1cccc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203.
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