
KDU-691
CAS No. 1513879-19-0
KDU-691( KDU691 )
Catalog No. M12114 CAS No. 1513879-19-0
KDU-691 is a potent, selective, orally active parasite PI4K inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 71 | In Stock |
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5MG | 109 | In Stock |
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10MG | 186 | In Stock |
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25MG | 397 | In Stock |
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50MG | 584 | In Stock |
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100MG | 833 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameKDU-691
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NoteResearch use only, not for human use.
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Brief DescriptionKDU-691 is a potent, selective, orally active parasite PI4K inhibitor.
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DescriptionKDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K); shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively; shows fully protective effect against P. cynomolgi sporozoites in animal models.
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In Vitro——
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In VivoDuring the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691.
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SynonymsKDU691
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PathwayPI3K/Akt/mTOR signaling
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TargetPI4K
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RecptorPI4K
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number1513879-19-0
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Formula Weight419.864
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Molecular FormulaC22H18ClN5O2
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Purity>98% (HPLC)
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SolubilityDMSO : 150 mg/mL. 357.26 mM
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SMILESClC1=CC=C(N(C(C2=CN3C(C=N2)=NC=C3C4=CC=C(C(NC)=O)C=C4)=O)C)C=C1
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Chemical NameN-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253.
2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63.
3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
molnova catalog



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