KDU-691

CAS No. 1513879-19-0

KDU-691( KDU691 )

Catalog No. M12114 CAS No. 1513879-19-0

KDU-691 is a potent, selective, orally active parasite PI4K inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 71 In Stock
5MG 109 In Stock
10MG 186 In Stock
25MG 397 In Stock
50MG 584 In Stock
100MG 833 In Stock
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Biological Information

  • Product Name
    KDU-691
  • Note
    Research use only, not for human use.
  • Brief Description
    KDU-691 is a potent, selective, orally active parasite PI4K inhibitor.
  • Description
    KDU-691 is a potent, selective, orally active parasite PI4K inhibitor with IC50 of 1.5 nM for P. vivax PI4K (PvPI4K); shows IC50 of 58 nM, 36 nM and 196 nM against P. falciparum (Pf, boold stages), P. yoelii (Py, schizont) and P. cynomolgi (Pc, hypnozoites) respectively; shows fully protective effect against P. cynomolgi sporozoites in animal models.
  • In Vitro
    ——
  • In Vivo
    During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691.
  • Synonyms
    KDU691
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI4K
  • Recptor
    PI4K
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1513879-19-0
  • Formula Weight
    419.864
  • Molecular Formula
    C22H18ClN5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 150 mg/mL. 357.26 mM
  • SMILES
    ClC1=CC=C(N(C(C2=CN3C(C=N2)=NC=C3C4=CC=C(C(NC)=O)C=C4)=O)C)C=C1
  • Chemical Name
    N-(4-Chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]imidazo[1,2-a]pyrazine-6-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. McNamara CW, et al. Nature. 2013 Dec 12;504(7479):248-253. 2. Zeeman AM, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2858-63. 3. Zou B, et al. ACS Med Chem Lett. 2014 Jul 6;5(8):947-50.
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