KDOAM-25 ( KDM5 inhibitor KDOAM 25 )

Catalog No. M13574 CAS No. 2230731-99-2

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Product Name

KDOAM-25
Note

Research use only, not for human use.
Brief Description

KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor.
Description

KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.
Synonyms

KDM5 inhibitor KDOAM 25
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

CAS Number

2230731-99-2
Formula Weight

307.40
Molecular Formula

C15H25N5O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCN(CCN(C)C)C(=O)CNCC1=NC=CC(=C1)C(=O)N
Chemical Name

2-[[[2-[2-(Dimethylamino)ethyl-Ethyl-Amino]-2-Oxidanylidene-Ethyl]amino]methyl]pyridine-4-Carboxamide

1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380.

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