KC7F2

Research use only, not for human use.

A small molecule HIF-1α translation inhibitor with IC50 of 20 uM.

A small molecule HIF-1α translation inhibitor with IC50 of 20 uM; prevents the activation of HIF-target genes such as CA IX, MMP2, Endothelin 1, and Enolase 1; down regulates of HIF-1α protein synthesis by suppression of the phosphorylation of 4EBP1 and p70S6K.

Cell Cytotoxicity Assay Cell Line:MCF7 cells, LNZ308 cells, A549 cells, U251MG cells, LN229 cells Concentration:15–25 μM Incubation Time:0-72 hours Result:With cytotoxicity more pronounced in tumor cell lines as compared to normal cells.Cell Viability Assay Cell Line:LN229 cells Concentration:6 hours Incubation Time:0 μM, 5 μM,7.5 μM,10 μM,15 μM,20 μM,30 μM,40 μM,60 μM,80 μM Result:Decreases HIF-1α protein levels in a dose-dependent manner.

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KC7F2

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF-1α

Cancer

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927822-86-4

570.3812

C16H16Cl4N2O4S4

>98% (HPLC)

DMSO: ≥ 32 mg/mL

ClC1=C(S(NCCSSCCNS(C2=C(Cl)C=CC(Cl)=C2)(=O)=O)(=O)=O)C=C(Cl)C=C1

Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-

(-20℃)

With Ice Pack

≥ 2 years