Cart
sales@molnova.com
KBP-5074
CAS No. 1359969-26-8
KBP-5074( KBP5074 | KBP 5074 )
Catalog No. M11476 CAS No. 1359969-26-8
KBP-5074 (KBP5074) is a novel non-steroidal, highly selective mineralocorticoid receptor antagonist for the treatment of hypertensive chronic kidney disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameKBP-5074
-
NoteResearch use only, not for human use.
-
Brief DescriptionKBP-5074 (KBP5074) is a novel non-steroidal, highly selective mineralocorticoid receptor antagonist for the treatment of hypertensive chronic kidney disease.
-
DescriptionKBP-5074 (KBP5074) is a novel non-steroidal, highly selective mineralocorticoid receptor antagonist for the treatment of hypertensive chronic kidney disease.Other Indication Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsKBP5074 | KBP 5074
-
PathwayNuclear Receptor/Transcription Factor
-
TargetMLR
-
RecptorMLR
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number1359969-26-8
-
Formula Weight504.031
-
Molecular FormulaC28H30ClN5O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1CCC(C1)C2C3CCC4=C(C3=NN2C5=CC(=C(C=C5)C#N)Cl)C=CC(=N4)C(=O)N6CCC(CC6)O
-
Chemical Name2-chloro-4-((3R,3aR)-3-cyclopentyl-7-(4-hydroxypiperidine-1-carbonyl)-3,3a,4,5-tetrahydro-2H-pyrazolo[3,4-f]quinolin-2-yl)benzonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Granberg K, et al. J Med Chem. 2018 Dec 31. doi: 10.1021/acs.jmedchem.8b01523.
molnova catalog
related products
-
CS-3150
CS-3150 (Esaxerenone, XL-550) is a?highly potent, selective and orally active non-steroidal mineralocorticoid receptor antagonist with IC50 of 9.4 nM.
-
PF-03882845
PF-03882845 is highly potent, selective, nonsteroidal, orally bioavailable Mineralocorticoid receptor antagonist with IC50 of 4.5 nM.
-
AZD 9977
AZD9977 is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).
