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K67
CAS No. 2046250-48-8
K67( —— )
Catalog No. M34303 CAS No. 2046250-48-8
K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameK67
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NoteResearch use only, not for human use.
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Brief DescriptionK67 competitively inhibits the interaction between Nrf2-ETGE and Keap1, inhibits the proliferation of HCC cells with high expression of S351 phosphorylated p62, and can be used to study cancer.
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DescriptionK67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetKeap1-Nrf2
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number2046250-48-8
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Formula Weight582.69
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Molecular FormulaC29H30N2O7S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (171.62 mM; Ultrasonic )
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SMILESO=C(C)CC=1C=C(NS(=O)(=O)C2=CC=C(OCC)C=C2)C=3C=CC=CC3C1NS(=O)(=O)C4=CC=C(OCC)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saito T, et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 2016 Jun 27;7:12030.?
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