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K-80003

CAS No. 1292821-90-9

K-80003( —— )

Catalog No. M32977 CAS No. 1292821-90-9

K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K-80003
  • Note
    Research use only, not for human use.
  • Brief Description
    K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
  • Description
    K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
  • In Vitro
    When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.
  • In Vivo
    K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    RAR/RXR? | Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1292821-90-9
  • Formula Weight
    336.4
  • Molecular Formula
    C22H21FO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 30 mg/mL (89.18 mM; Ultrasonic )
  • SMILES
    CC(C)c1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73.?
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