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K-777
CAS No. 749860-43-3
K-777( K 777 | K777 )
Catalog No. M15857 CAS No. 749860-43-3
K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameK-777
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NoteResearch use only, not for human use.
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Brief DescriptionK-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
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DescriptionK-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively; induces CCR4 internalization, reduces cell surface CCR4.
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In Vitro——
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In Vivo——
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SynonymsK 777 | K777
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number749860-43-3
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Formula Weight641.5
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Molecular FormulaC28H32F4IN5
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-(1-(4-((2,4-difluorobenzyl)amino)-5-(2,4-difluorophenyl)pyrimidin-2-yl)piperidin-4-yl)-1-methylpiperidin-1-ium
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sato T, et al. Pharmacology. 2013;91(5-6):305-13.
2. Solari R, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt B):169-77.
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