K-604
CAS No. 217094-32-1
K-604 ( K604 )
Catalog No. M13469 CAS No. 217094-32-1
K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 67 | Get Quote |
|
5MG | 110 | Get Quote |
|
10MG | 177 | Get Quote |
|
25MG | 357 | Get Quote |
|
50MG | 530 | Get Quote |
|
100MG | 759 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameK-604
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NoteResearch use only, not for human use.
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Brief DescriptionK-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
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DescriptionK-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2; inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I; suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.Atherosclerosis Phase 2 Clinical
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SynonymsK604
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCardiovascular Disease
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IndicationAtherosclerosis
Chemical Information
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CAS Number217094-32-1
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Formula Weight575.63
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Molecular FormulaC23H32Cl2N6OS3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl
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Chemical Name4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
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