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K-604

CAS No. 217094-32-1

K-604 ( K604 )

Catalog No. M13469 CAS No. 217094-32-1

K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    K-604
  • Note
    Research use only, not for human use.
  • Brief Description
    K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2.
  • Description
    K-604 is a potent, selective and competitive ACAT-1 inhibitor with IC50 of 0.45 uM for human ACAT-1, displays 229-fold selectivity over ACAT-2; inhibits cholesterol esterification in human monocyte-derived macrophages with IC50 of 60 nM, enhances cholesterol efflux from THP-1 macrophages to HDL3 or apolipoprotein A-I; suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.Atherosclerosis Phase 2 Clinical
  • Synonyms
    K604
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Atherosclerosis

Chemical Information

  • CAS Number
    217094-32-1
  • Formula Weight
    575.63
  • Molecular Formula
    C23H32Cl2N6OS3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC.Cl.Cl
  • Chemical Name
    4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ikenoya M, et al. Atherosclerosis. 2007 Apr;191(2):290-7.
2. Shibuya Y, et al. J Neurosci. 2014 Oct 22;34(43):14484-501.
3. Yoshinaka Y, et al. Atherosclerosis. 2010 Nov;213(1):85-91.
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