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Home - Products - Metabolic Enzyme/Protease - Lipase - JZP-361

JZP-361

CAS No. 1680193-80-9

JZP-361( —— )

Catalog No. M34301 CAS No. 1680193-80-9

JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JZP-361
  • Note
    Research use only, not for human use.
  • Brief Description
    JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6.
  • Description
    JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research.
  • In Vitro
    JZP-361 has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50 = 7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50 = 1.79 μM).JZP-361 retains H1 antagonistic affinity (pA2 = 6.81) but did not show cannabinoid receptor activity, when tested at concentrations ≤10 μM.JZP-361 displays favorable interactions within the active site of hMAGL including the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Lipase
  • Recptor
    Lipase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1680193-80-9
  • Formula Weight
    405.88
  • Molecular Formula
    C22H20ClN5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (307.97 mM; Ultrasonic (<60°C)
  • SMILES
    Clc1ccc2c(CCc3cccnc3C2=C2CCN(CC2)C(=O)n2cncn2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jayendra Z Patel,?et al. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett.?2015 Apr 1;25(7):1436-42.?
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