JZL184 ( JZL184; JZL 184; JZL-184 )

Catalog No. M17810 CAS No. 1101854-58-3

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Product Name

JZL184
Note

Research use only, not for human use.
Brief Description

JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
Description

JZL184 is highly selective, and potent MAGL inhibitor ( monoacylglycerol lipase inhibitor). JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. JZL184 also suppresses inflammatory pain in the mouse carrageenan model.
Synonyms

JZL184; JZL 184; JZL-184
Pathway

Others
Target

Other Targets
Recptor

MAGL
Research Area

Neurological Disease
Indication

——

CAS Number

1101854-58-3
Formula Weight

520.49
Molecular Formula

C27H24N2O9
Purity

98%
Solubility

DMSO : ≥ 35 mg/mL; 67.24 mM
SMILES

OC(C1CCN(CC1)C(=O)Oc1ccc(cc1)[N+](=O)[O-])(c1ccc2OCOc2c1)c1ccc2OCOc2c1
Chemical Name

4-nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate.

1. Long JZ, et al. Nat Chem Biol, 2009, 5(1), 37-44.

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