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JW-7-25-1
CAS No. 1222998-57-3
JW-7-25-1( JW-7-25-1 | JW 7-25-1 | JW7-25-1 )
Catalog No. M10849 CAS No. 1222998-57-3
JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameJW-7-25-1
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NoteResearch use only, not for human use.
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Brief DescriptionJW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM.
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DescriptionJW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM; exhibits a broad kinase selectivity profile with an S(35) score of 0.54 at 10 uM.
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In Vitro——
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In Vivo——
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SynonymsJW-7-25-1 | JW 7-25-1 | JW7-25-1
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PathwayPI3K/Akt/mTOR signaling
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TargetMELK
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RecptorMELK
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Research Area——
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Indication——
Chemical Information
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CAS Number1222998-57-3
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Formula Weight516.524
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Molecular FormulaC29H23F3N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1N(C2=CC=C(N3CCNCC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC=C(O)C=C6)C=C54)C=C1
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Chemical Name9-(4-hydroxyphenyl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
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