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JTE-952

CAS No. 1255303-54-8

JTE-952( JTE952 | JTE 952 )

Catalog No. M11037 CAS No. 1255303-54-8

JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JTE-952
  • Note
    Research use only, not for human use.
  • Brief Description
    JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM.
  • Description
    JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM; JTE-952 is also effective against a mouse collagen-induced model of arthritis (mouse CIA-model).
  • In Vitro
    ——
  • In Vivo
    JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model). Animal Model:Mouse model of collagen-induced arthritis (CIA model).Dosage:3 mg/kg.Administration:Oral once-daily.Result:Reduced the overall progression of the clinical score, including inflammation and bone erosion.
  • Synonyms
    JTE952 | JTE 952
  • Pathway
    Tyrosine Kinase
  • Target
    CSF1R
  • Recptor
    CSF1R
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1255303-54-8
  • Formula Weight
    518.61
  • Molecular Formula
    C30H34N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (192.83 mM)
  • SMILES
    O=C(N1CC(C2=CC=C(OCC3=CC=C(C4CC4)C=C3)C(OC)=C2)C1)C5=NC=CC(COC[C@@H](O)CO)=C5
  • Chemical Name
    (S)-(3-(4-((4-cyclopropylbenzyl)oxy)-3-methoxyphenyl)azetidin-1-yl)(4-((2,3-dihydroxypropoxy)methyl)pyridin-2-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ikegashira K, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877.
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