JSH-150

CAS No. 2247481-21-4

JSH-150 ( JSH150;JSH 150 )

Catalog No. M13607 CAS No. 2247481-21-4

JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 82 Get Quote
10MG 141 Get Quote
25MG 314 Get Quote
50MG 485 Get Quote
100MG 586 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    JSH-150
  • Note
    Research use only, not for human use.
  • Brief Description
    JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM).
  • Description
    JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM); also exhibits high selectivity over other 468 kinases/mutants (KINOMEscan S score(1)=0.01); displays potent antiproliferative effects against melanoma, neuroblastoma, hepatoma, colon cancer, lung cancer as well as leukemia cell lines, dose-dependently inhibits the phosphorylation of RNA Pol II, suppresses the expression of MCL-1 and c-Myc, arreststhe cell cycle and induces the apoptosis in the leukemia cells; completely suppresses the tumor progression in MV4-11 cell-inoculated xenograft mouse model (10 mg/kg).
  • Synonyms
    JSH150;JSH 150
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2247481-21-4
  • Formula Weight
    505.08
  • Molecular Formula
    C24H33ClN6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COCCNC1CC[C@H](NC2=NC=C(Cl)C(C3=CSC(NCC4(C#N)CCOCC4)=N3)=C2)CC1
  • Chemical Name
    4-(((4-(5-Chloro-2-(((1r,4r)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang B, et al. Eur J Med Chem. 2018 Oct 5;158:896-916.
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