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JR14a
CAS No. 2411440-41-8
JR14a( 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride )
Catalog No. M24104 CAS No. 2411440-41-8
JR14a is a potent antagonist of human complement C3a receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 178 | In Stock |
|
| 10MG | 282 | In Stock |
|
| 25MG | 480 | In Stock |
|
| 50MG | 691 | In Stock |
|
| 100MG | 972 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJR14a
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NoteResearch use only, not for human use.
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Brief DescriptionJR14a is a potent antagonist of human complement C3a receptor.
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DescriptionJR14a is a potent antagonist of human complement C3a receptor.
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In Vitro——
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In VivoAnimal Model:Male Wister rats (8 weeks, 250-300 g) were injected with BR103Dosage:10 mg/kg Administration:P.o. 2 h prior to agonist challenge Result:Inhibited C3aR-mediated inflammation.Animal Model:Male Wister rats (8 weeks, 250-300 g)Dosage:1 mg/kg for i.v.; 10 mg/kg for oral (Pharmacokinetic Analysis) Administration:Intravenous administration and oral administration Result:I.v.: t1/2=191 min, clearance=4.4 mL/min/kg, AUC=3795 ng?h/mL.P.o.: Cmax=88 ng/mL, Tmax=300 min, AUC=478 ng?h/mL.
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Synonyms5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride
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PathwayOthers
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TargetOther Targets
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RecptorC3a
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Research Area——
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Indication——
Chemical Information
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CAS Number2411440-41-8
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Formula Weight533.47
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Molecular FormulaC25H26Cl2N4O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 90 mg/mL?(168.71 mM;?Need ultrasonic)
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SMILESCc1c(C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)sc(C(c(cc2)ccc2Cl)c(cc2)ccc2Cl)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rowley JA, et, al. Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity. J Med Chem. 2020 Jan 23;63(2):529-541.
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