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JR14a

CAS No. 2411440-41-8

JR14a( 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride )

Catalog No. M24104 CAS No. 2411440-41-8

JR14a is a potent antagonist of human complement C3a receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JR14a
  • Note
    Research use only, not for human use.
  • Brief Description
    JR14a is a potent antagonist of human complement C3a receptor.
  • Description
    JR14a is a potent antagonist of human complement C3a receptor.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Wister rats (8 weeks, 250-300 g) were injected with BR103Dosage:10 mg/kg Administration:P.o. 2 h prior to agonist challenge Result:Inhibited C3aR-mediated inflammation.Animal Model:Male Wister rats (8 weeks, 250-300 g)Dosage:1 mg/kg for i.v.; 10 mg/kg for oral (Pharmacokinetic Analysis) Administration:Intravenous administration and oral administration Result:I.v.: t1/2=191 min, clearance=4.4 mL/min/kg, AUC=3795 ng?h/mL.P.o.: Cmax=88 ng/mL, Tmax=300 min, AUC=478 ng?h/mL.
  • Synonyms
    5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    C3a
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2411440-41-8
  • Formula Weight
    533.47
  • Molecular Formula
    C25H26Cl2N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 90 mg/mL?(168.71 mM;?Need ultrasonic)
  • SMILES
    Cc1c(C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)sc(C(c(cc2)ccc2Cl)c(cc2)ccc2Cl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rowley JA, et, al. Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity. J Med Chem. 2020 Jan 23;63(2):529-541.
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