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JPH203

CAS No. 1037592-40-7

JPH203 ( KYT-0353;KYT0353;KYT 0353;JPH-203 )

Catalog No. M10188 CAS No. 1037592-40-7

JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JPH203
  • Note
    Research use only, not for human use.
  • Brief Description
    JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
  • Description
    JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2; inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively; significant inhibits HT-29 tumor growth in vivo.Solid Tumors Phase 1 Clinical
  • Synonyms
    KYT-0353;KYT0353;KYT 0353;JPH-203
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1037592-40-7
  • Formula Weight
    472.32
  • Molecular Formula
    C23H19Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N
  • Chemical Name
    L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
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