Cart
sales@molnova.com
Home - Products - Apoptosis - Apoptosis - JPH203

JPH203

CAS No. 1037592-40-7

JPH203 ( KYT-0353;KYT0353;KYT 0353;JPH-203 )

Catalog No. M10188 CAS No. 1037592-40-7

JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 53 Get Quote
5MG 76 Get Quote
10MG 109 Get Quote
25MG 182 Get Quote
50MG 327 Get Quote
100MG 420 Get Quote
200MG 620 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    JPH203
  • Note
    Research use only, not for human use.
  • Brief Description
    JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
  • Description
    JPH203 (KYT-0353)is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2; inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively; significant inhibits HT-29 tumor growth in vivo.Solid Tumors Phase 1 Clinical
  • Synonyms
    KYT-0353;KYT0353;KYT 0353;JPH-203
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1037592-40-7
  • Formula Weight
    472.32
  • Molecular Formula
    C23H19Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N
  • Chemical Name
    L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Puromycin aminonucle...

    Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.Puromycin aminonucleoside -induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside causes podocyte apoptosis in a time-dependent manner.

  • DC_AC50

    DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones).

  • Iberin

    Iberin is an isothiocyanate compound from horseradish that exhibits anticancer activity.

Sign In Join Free