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JPH203
CAS No. 1037592-40-7
JPH203( KYT-0353 | KYT0353 | KYT 0353 | JPH-203 )
Catalog No. M10188 CAS No. 1037592-40-7
JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 53 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 109 | In Stock |
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| 25MG | 182 | In Stock |
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| 50MG | 327 | In Stock |
|
| 100MG | 420 | In Stock |
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| 200MG | 620 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJPH203
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NoteResearch use only, not for human use.
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Brief DescriptionJPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
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DescriptionJPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2; inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively; significant inhibits HT-29 tumor growth in vivo.Solid Tumors Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsKYT-0353 | KYT0353 | KYT 0353 | JPH-203
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1037592-40-7
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Formula Weight472.32066
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Molecular FormulaC23H19Cl2N3O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N
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Chemical NameL-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
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