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JNK-IN-8

CAS No. 1410880-22-6

JNK-IN-8( JNK-IN-8 | c-Jun N-terminal Kinase Inhibitor XVI )

Catalog No. M11713 CAS No. 1410880-22-6

JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JNK-IN-8
  • Note
    Research use only, not for human use.
  • Brief Description
    JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively.
  • Description
    JNK-IN-8 is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively; exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling; inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNK-IN-8 | c-Jun N-terminal Kinase Inhibitor XVI
  • Pathway
    MAPK/ERK Signaling
  • Target
    JNK
  • Recptor
    JNK1|JNK2|JNK3|Kit(V559D)|Kit(V559D,T670I)
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1410880-22-6
  • Formula Weight
    507.6
  • Molecular Formula
    C29H29N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    CN(C/C=C/C(NC1=CC=CC(C(NC2=CC=C(C(C)=C2)NC3=NC=CC(C4=CN=CC=C4)=N3)=O)=C1)=O)C
  • Chemical Name
    Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang T, et al. Chem Biol. 2012 Jan 27;19(1):140-54.
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