JNJ-63576253 ( TRC253 )

Catalog No. M23961 CAS No. 2110426-27-0

JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells.?

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	50	In Stock
5MG	73	In Stock
10MG	123	In Stock
25MG	255	In Stock
50MG	407	In Stock
100MG	599	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

JNJ-63576253
Note

Research use only, not for human use.
Brief Description

JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells.?
Description

JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells.?JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
Synonyms

TRC253
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

androgen receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

2110426-27-0
Formula Weight

502.5
Molecular Formula

C23H21F3N6O2S
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 28;64(2):909-924.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks