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JNJ-42153605
CAS No. 1254977-87-1
JNJ-42153605 ( JNJ-42153605; JNJ 42153605; JNJ42153605 )
Catalog No. M17222 CAS No. 1254977-87-1
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
Purity : 97%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 74 | In Stock |
|
| 5MG | 132 | In Stock |
|
| 10MG | 194 | In Stock |
|
| 25MG | 353 | In Stock |
|
| 50MG | 530 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJNJ-42153605
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).
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DescriptionJNJ-42153605 is a potent and selective mGlu2 receptor PAM with an acceptable pharmacokinetic profile in rodent and nonrodent species. JNJ-42153605 showed centrally mediated in vivo effectivity in models sensitive to mGlu2 receptor modulation such as sleepwake electroencephalogram (sw-EEG) in rats,34 showing suppressed REM sleep during the first 4 h after oral administration of a 3 mg/kg dose.
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SynonymsJNJ-42153605; JNJ 42153605; JNJ42153605
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptormGluR2 PAM
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Research Area——
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Indication——
Chemical Information
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CAS Number1254977-87-1
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Formula Weight400.45
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Molecular FormulaC22H23F3N4
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Purity97%
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Solubility——
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SMILESc12c(c(ccn1c(nn2)CC1CC1)N1CCC(CC1)c1ccccc1)C(F)(F)F
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Chemical Name3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cid JM, et al. J Med Chem. 2012 Oct 25;55(20):8770-89.
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