JNJ-31020028 ( JNJ31020028; JNJ 31020028; JNJ-31020028 )

Catalog No. M10369 CAS No. 1094873-14-9

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HNMR

HPLC

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Product Name

JNJ-31020028
Note

Research use only, not for human use.
Brief Description

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat).
Description

JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
Synonyms

JNJ31020028; JNJ 31020028; JNJ-31020028
Pathway

Others
Target

Other Targets
Recptor

Y2 receptor
Research Area

Neurological Disease
Indication

——

CAS Number

1094873-14-9
Formula Weight

565.68
Molecular Formula

C34H36FN5O2
Purity

>98%(HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C(NC1=CC=C(N2CCN(C(C3=CC=CC=C3)C(N(CC)CC)=O)CC2)C(F)=C1)C4=CC=CC=C4C5=CC=CN=C5
Chemical Name

N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide

1.Shoblock JR, et al. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.

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