JNJ-26489112 ( JNJ26489112 )

Catalog No. M16338 CAS No. 871824-55-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

JNJ-26489112
Note

Research use only, not for human use.
Brief Description

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures.
Description

JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models.Epilepsy Discontinued
Synonyms

JNJ26489112
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Neurological Disease
Indication

Epilepsy

CAS Number

871824-55-4
Formula Weight

278.71
Molecular Formula

C9H11ClN2O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(NC[C@@H]1OC2=CC=C(Cl)C=C2OC1)(N)=O
Chemical Name

(S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide

1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30.

Calculator

molnova catalog