JNJ 303( —— )

Catalog No. M20998 CAS No. 878489-28-2

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

JNJ 303
Note

Research use only, not for human use.
Brief Description

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
Description

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
In Vitro

JNJ 303 can block IKs with an IC50 value of 64 nM. JNJ 303 (3.3 μM) does not have any effects on other cardiac channels.JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
In Vivo

JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

IKs
Research Area

——
Indication

——

Chemical Information

CAS Number

878489-28-2
Formula Weight

440.98
Molecular Formula

C21H29ClN2O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (141.73 mM)
SMILES

CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1C2CC3CC1CC(NS(C)(=O)=O)(C3)C2
Chemical Name

2-(4-Chloro-phenoxy)-N-(5-methanesulfonylamino-adamantan-2-yl)-2-methyl-propionamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kang C Badiceanu A Brennan J A et al. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle[J]. Scientific Reports 2017 7(1):15922.

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