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JK-P3

CAS No. 942655-44-9

JK-P3 ( 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide )

Catalog No. M17680 CAS No. 942655-44-9

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 88 In Stock
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Biological Information

  • Product Name
    JK-P3
  • Note
    Research use only, not for human use.
  • Brief Description
    JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays.
  • Description
    JK-P3 is novel inhibitor of VEGFR-2. JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.
  • Synonyms
    3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    VEGFR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    942655-44-9
  • Formula Weight
    323.35
  • Molecular Formula
    C18H17N3O3
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    COc1c(cc(cc1)C(=O)Nc1n[nH]c(c1)c1ccccc1)OC
  • Chemical Name
    3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Antony M. Latham, et al. Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. VEGF Signaling pp 121-131
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