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JI051

CAS No. 2234281-75-3

JI051( —— )

Catalog No. M32973 CAS No. 2234281-75-3

JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JI051
  • Note
    Research use only, not for human use.
  • Brief Description
    JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.
  • Description
    JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.
  • In Vitro
    JI051 causes G2/M cell-cycle arrest.JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.Cell Proliferation Assay Cell Line:HEK293 cells Concentration:0.1-10 μM Incubation Time:24 hours Result:Dose-dependently inhibits the proliferation of HEK293 cells at low concentrations.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    Gamma-secretase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2234281-75-3
  • Formula Weight
    364.44
  • Molecular Formula
    C22H24N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (342.99 mM; Ultrasonic )
  • SMILES
    CCOc1ccccc1CCNC(=O)\C=C\c1c[nH]c2c(OC)cccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294.?
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