JI-101 ( JI101, JI 101, JI-101 )

Catalog No. M17651 CAS No. 900573-88-8

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Product Name

JI-101
Note

Research use only, not for human use.
Brief Description

JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).
Description

JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis.
Synonyms

JI101, JI 101, JI-101
Pathway

Others
Target

Other Targets
Recptor

Ephrin Receptor; PDGFR; VEGFR
Research Area

Cardiovascular Disease
Indication

——

CAS Number

900573-88-8
Formula Weight

466.34
Molecular Formula

C22H20BrN5O2
Purity

98%
Solubility

DMSO : ≥ 100 mg/mL; 214.44 mM
SMILES

N(C(=O)Nc1c(ccc(c1)Br)OC)c1c2ccn(c2ccc1)Cc1cc(ncc1)N
Chemical Name

1-(1-((2-aminopyridin-4-yl)methyl)-1H-indol-4-yl)-3-(5-bromo-2-methoxyphenyl)urea.

1.Mark L. Wade, Neeraj Agarwal et al. Investigational New Drugs, December 2015, Volume 33, Issue 6, pp 1217-1224

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