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JH-X-119-01
CAS No. 2227368-54-7
JH-X-119-01( —— )
Catalog No. M24010 CAS No. 2227368-54-7
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 200 | In Stock |
|
| 25MG | 356 | In Stock |
|
| 50MG | 533 | In Stock |
|
| 100MG | 740 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJH-X-119-01
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NoteResearch use only, not for human use.
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Brief DescriptionJH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
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DescriptionJH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
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In VitroWestern Blot Analysis Cell Line:RAW 264.7 cells and THP-1 cells Concentration:10 μM Incubation Time:15 minutes Result:Decreased LPS (100 ng/mL)-induced phosphorylation of IκBα and NF-κB-P65.
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In VivoAnimal Model:C57BL/6 (20-22 g, male) mice Dosage:5 mg/kg and 10 mg/kg Administration:Intraperitoneally injected; 5 days Result:Protected mice from LPS (20 mg/kg)-induced sepsis. Survival at day 5 was 13.3% in control group where septic mice were treated by vehicle, while the values were 37.5% and 56.3% for 5 mg/kg and 10 mg/kg.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIRAK
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RecptorIRAK-1
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Research Area——
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Indication——
Chemical Information
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CAS Number2227368-54-7
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Formula Weight452.46
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Molecular FormulaC25H20N6O3
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Purity>98% (HPLC)
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SolubilityDMSO:Soluble
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SMILESO=C(C1=NC(C2=NNC=C2)=CC=C1)NC3=CC=C(NC(C4=CC=CC(NC(C=C)=O)=C4)=O)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.John M Hatcher, et al.ACS Med Chem Lett.2020 Oct 9;11(11):2238-2243.
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