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JG26

CAS No. 1464910-32-4

JG26( —— )

Catalog No. M34294 CAS No. 1464910-32-4

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	126	Get Quote
5MG	188	Get Quote
10MG	282	Get Quote
25MG	481	Get Quote
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Biological Information

Product Name

JG26
Note

Research use only, not for human use.
Brief Description

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively.
Description

JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Immunology/Inflammation related | MMP
Research Area

——
Indication

——

Chemical Information

CAS Number

1464910-32-4
Formula Weight

594.27
Molecular Formula

C19H22Br2N4O6S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (168.27 mM; Ultrasonic )
SMILES

S(N[C@H](CCCNC(N)=O)C(NO)=O)(=O)(=O)C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Doretta Cuffaro, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793.?

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