JC-1

Research use only, not for human use.

JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.

JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells. Fluorescent labeling of mitochondria with either JC-1 (1 μg/mL, 15 min), reveals that are distributed irregularly, resulting in regions of high and low mitochondrial content within astrocytes. JC-1 is avidly accumulated in sensitive K562 cells where it displays both a green cytoplasmic and red mitochondrial fluorescence. JC-1 is poorly accumulated in resistant K562 cells, which displays only a slight green fluorescence. JC-1 has been shown to interact with α-synuclein at the acidic C-terminal region with a Kd of 2.6 μM. JC-1 itself does not accelerate the protein aggregation of α-synuclein in the absence of iron, insted, it decelerates the aggregation process by extending the lag phase approx.

CBIC2

Others

Other Targets

Others

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3520-43-2

652.23

C25H27Cl4IN4

>98% (HPLC)

DMSO:14 mg/mL(21.46 mM)

[I-].CCN1\C(=C/C=C/c2n(CC)c3cc(Cl)c(Cl)cc3[n+]2CC)N(CC)c2cc(Cl)c(Cl)cc12

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(-20℃)

With Ice Pack

≥ 2 years