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JAK1-IN-31
CAS No. 1315498-72-6
JAK1-IN-31( —— )
Catalog No. M11278 CAS No. 1315498-72-6
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJAK1-IN-31
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NoteResearch use only, not for human use.
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Brief DescriptionJAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM.
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DescriptionJAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1315498-72-6
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Formula Weight449.529
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Molecular FormulaC23H23N5O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Nametrans-4-(2-((R)-1-Hydroxyethyl)-6-(phenylsulfonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85.
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