J-14 ( —— )

Catalog No. M21559 CAS No. 1043854-13-2

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM).?J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	87	Get Quote
25MG	142	Get Quote
50MG	218	Get Quote
100MG	370	Get Quote
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Biological Information

Product Name

J-14
Note

Research use only not for human use.
Brief Description

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM).?J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.
Description

J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM).?J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin leading to cytotoxicity and cancer cell death.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

sulfiredoxin
Research Area

——
Indication

——

Chemical Information

CAS Number

1043854-13-2
Formula Weight

517.04
Molecular Formula

C28H25ClN4O2S
Purity

>98% (HPLC)
Solubility

DMSO:260 mg/mL (502.86 mM; Need ultrasonic)
SMILES

OC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kim H et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74.

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