Ivermectin

Research use only, not for human use.

Ivermectin is a broad-spectrum antiparasitic drug in the avermectin family. It is taken internally or used topically, depending on the treated condition.

Ivermectin is a broad-spectrum antiparasitic drug in the avermectin family. It is taken internally or used topically, depending on the treated condition.

In the submicromolar range (EC50=250 nM) the action of Ivermectin (MK-933) is rapid and reversible, resulting in increased amplitude and slowed deactivation of P2X4 channel currents evoked by ATP. Ivermectin (MK-933) markedly increases the potency of ATP and that of the normally low-potency agonist a,b-methylene-ATP in a use- and voltage-independent manner without changing the ion selectivity of P2X4 channels.Ivermectin (MK-933) activates glutamate-gated chloride channels in the nerves and muscles of the parasite, leading to membrane hyperpolarization and muscle paralysis.Ivermectin (MK-933) strongly inhibits the binding of Impα/β1 to NS5 (IC50=17 μM), but not of Impβ1 alone to NS5.Ivermectin (MK-933) has potent antiviral activity towards both HIV-1 and dengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively.

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MK-933 | Ivermectin | Ivomec | L 64047 | 1 Mectizan | MK 933 | MK-0933 | Noromectin | Pandex

Microbiology/Virology

GluCls

GluCl channels| P2 receptor

Infection

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70288-86-7

875.09

C48H74O14

>98% (HPLC)

Ethanol: 28 mg/mL (31.99 mM); DMSO: 175 mg/mL (199.97 mM)

CCC([C@@H]1[C@@H](C)CC[C@]2(CC3C[C@@H](C/C=C(C)/[C@@H](O[C@H]4C[C@H](OC)[C@@H](OC5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C6CO[C@H]7[C@]\6(O)[C@H](C(O3)=O)C=C(C)[C@H]7O)O2)O1)C.C[C@H]8CC[C@@]9(O[C@@H]8C(C)C)CC%10C[C@@H](C/C=C(C)/[C@@H](O[C@H]%11C[C@H](OC)[C@@H](OC%12C[C@H](OC)[C@@H](O)[C@H](C)O%12)[C@H](C)O%11)[C@@H](C)/C=C/C=C%13CO[C@H]%14[C@]\%13(O)[C@H](C(O%10)=O)C=C(C)[C@H]%14O)O9

22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b

(-20℃)

With Ice Pack

≥ 2 years