Itraconazole

Research use only, not for human use.

A triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase.

A triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase; also has been shown to inhibit both the hedgehog signaling pathway and angiogenesis.Fungal Infection Approved(In Vitro):Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM).Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.(In Vivo):Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.

Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM).Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro.

Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model. Animal Model:Female outbred athymic nude mice (6-7-week-old) injected with Ptch+/? cells Dosage:75 mg/kg, 100 mg/kg Administration:Oral gavage; twice per day; for 18 days Result:Suppressed Hh pathway activity and the growth of medulloblastoma in a mouse allograft model.

R51211

Microbiology/Virology

Fungal

CYP3A4

Infection

Fungal Infection

84625-61-6

705.6334

C35H38Cl2N8O4

>98% (HPLC)

DMSO: ≥ 7.3 mg/mL

O=C1N(C(CC)C)N=CN1C2=CC=C(N3CCN(C4=CC=C(OC[C@@H]5O[C@@](CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2

3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-

(-20℃)

With Ice Pack

≥ 2 years