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Itacitinib

CAS No. 1334298-90-6

Itacitinib( INCB-039110 )

Catalog No. M11330 CAS No. 1334298-90-6

A potent and selective JAK1 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Itacitinib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective JAK1 inhibitor.
  • Description
    A potent and selective JAK1 inhibitor; shows >20 fold and >200 fold selectivity over JAK2 and JAK3 respectively; orally bioactive.Blood Cancer Phase 2 Clinical(In Vitro):Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.
  • In Vitro
    Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis.
  • In Vivo
    ——
  • Synonyms
    INCB-039110
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK1
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1334298-90-6
  • Formula Weight
    553.5142
  • Molecular Formula
    C26H23F4N9O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1
  • Chemical Name
    3-Azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang Y, et al. Drug Metab Dispos. 2015 Apr;43(4):485-9. 2. Kim MK, et al. J Med Chem. 2015 Sep 24;58(18):7596-602. 3. Norman P. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77.
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