Isbufylline
CAS No. 90162-60-0
Isbufylline ( —— )
Catalog No. M28920 CAS No. 90162-60-0
Isbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
|
10MG | 581 | Get Quote |
|
25MG | 888 | Get Quote |
|
50MG | 1242 | Get Quote |
|
100MG | 1674 | Get Quote |
|
500MG | 3348 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameIsbufylline
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NoteResearch use only, not for human use.
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Brief DescriptionIsbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity.
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DescriptionIsbufylline can exert significant anti-inflammatory actions, in addition to its bronchodilator activity.(In Vivo):At a dose (106 μmol/kg i.p.) providing complete protection against acetylcholine aerosol-induced dyspnea in the guinea pig, Isbufylline inhibited platelet-activating factor (PAF)- and antigen-induced eosinophil infiltration into bronchoalveolar lavage fluid 24 h after the challenge of normal and actively immunized guinea pigs, respectively. In addition, this dose of Isbufylline also inhibited capsaicin-induced extravasation of protein into bronchoalveolar lavage fluid. Isbufylline, 4.2 μmol/kg i.v., significantly inhibited PAF-induced bronchial hyper-responsiveness to i.v. histamine, without exerting evident bronchodilator activity. On the other hand, the bronchodilator, salbutamol, at a dose (10.4 μmol/kg i.p.) was shown to be equieffective to Isbufylline (106 μmol/kg i.p.) for blocking acetylcholine aerosol-induced dyspnea, had no protective action against PAF- or antigen-induced eosinophil recruitment in bronchoalveolar lavage fluid, or against capsaicin-induced plasma protein extravasation. Furthermore, salbutamol (3.5 μmol/kg) significantly potentiated allergen-induced cell infiltration and PAF-induced bronchial hyperresponsiveness.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number90162-60-0
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Formula Weight236.3
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Molecular FormulaC11H16N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Morikawa T, et al. Ellagic acid glycosides with hepatoprotective activity from traditional Tibetan medicine Potentilla anserina. J Nat Med. 2018 Jan;72(1):317-325.
molnova catalog
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