Irosustat

Research use only, not for human use.

Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity.

Irosustat, also known as STX64, BN83495 and 667 coumate, is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.

STX64; STX-64; STX 64; BN83495; COUMATE. Irosustat

Others

Other Targets

steroid sulfatase

Cancer

——

288628-05-7

309.34

C14H15NO5S

98%

DMSO : ≥ 150 mg/mL; 484.90 mM

NS(=O)(=O)Oc2ccc3C=1CCCCCC=1C(=O)Oc3c2

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate.

(-20℃)

With Ice Pack

≥ 2 years