Indirubin ( Indirubin; C.I. 73200, Couroupitine B, NSC 105327 )

Catalog No. M18602 CAS No. 479-41-4

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HNMR

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Product Name

Indirubin
Note

Research use only, not for human use.
Brief Description

Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
Description

Indirubin is a potent and selective CDK inhibitor. Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin has been used to treat the symptoms of leukemia. Further biological explorations revealed the ability of indirubin to bind cyclin-dependent kinases and 6-bromoindirubin, extracted from mollusks, to bind glycogen synthase kinase-3. Studies have shown that Indirubin can help keep cancer cells from reproducing in rats. Indirubin also appears to reduce inflammation by inhibiting part of the immune response.
Synonyms

Indirubin; C.I. 73200, Couroupitine B, NSC 105327
Pathway

Others
Target

Other Targets
Recptor

GSK-3β , CDK2/CyclinA , CDK5/p35 , CDK1/CyclinB , C-Raf
Research Area

Cancer
Indication

——

CAS Number

479-41-4
Formula Weight

262.26
Molecular Formula

C16H10N2O2
Purity

98%
Solubility

DMSO : ≥ 41 mg/mL; 156.33 mM
SMILES

C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2
Chemical Name

3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one

1. Hoessel R, et al. Nat Cell Biol, 1999, 1(1), 60-67.

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