InS3-54A18 ( inS3-54-A18; inS3-54A18; inS3-54 A18; inS354-A18 )

Catalog No. M14081 CAS No. 328998-53-4

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Datasheet

HNMR

HPLC

MSDS

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Product Name

InS3-54A18
Note

Research use only, not for human use.
Brief Description

InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay.
Description

InS3-54A18 is an active analog of inS3-54 targeting the DBD of STAT3 with IC50 of 8.8 uM in STAT3-dependent luciferase reporter assay, with increased specificity and pharmacological properties; not only binds directly to the DBD and inhibits the DNA-binding activity of STAT3 both in vitro and in situ but also effectively inhibits the constitutive and IL-6-stimulated expression of STAT3 downstream target genes; InS3-54A18 is completely soluble in an oral formulation and effectively inhibits lung xenograft tumor growth and metastasis with little adverse effect on animals.
Synonyms

inS3-54-A18; inS3-54A18; inS3-54 A18; inS354-A18
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

Cancer
Indication

——

CAS Number

328998-53-4
Formula Weight

373.84
Molecular Formula

C23H16ClNO2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 150 mg/mL 401.25 mM
SMILES

O=C1N(C2=CC=C(O)C=C2)C(C3=CC=CC=C3)=C/C1=C/C4=CC=C(Cl)C=C4
Chemical Name

3-(4-chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one

1. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.

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