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Home - Products - JAK/STAT Signaling - STAT - InS3-54

InS3-54

CAS No. 328998-92-1

InS3-54( —— )

Catalog No. M14082 CAS No. 328998-92-1

An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    InS3-54
  • Note
    Research use only, not for human use.
  • Brief Description
    An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3.
  • Description
    An STAT3 inhibitor that selectively targets the DNA-binding domain of STAT3, without affecting the activation and dimerization of STAT3; preferentially suppresses proliferation of cancer over non-cancer cells and inhibits migration and invasion of malignant cells; selectively inhibits STAT3 binding to DNA without affecting the activation and dimerization of STAT3; inhibits expression of STAT3 downstream target genes and STAT3 binding to chromatin in situ.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328998-92-1
  • Formula Weight
    412.401
  • Molecular Formula
    C24H16N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (E)-4-(3-(4-nitrobenzylidene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang W, et al. ACS Chem Biol. 2014 May 16;9(5):1188-96. 2. Huang W, et al. Oncogene. 2016 Feb 11;35(6):783-92.
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