Ibiglustat ( Venglustat;Genz-682452;GZ452 )

Catalog No. M11673 CAS No. 1401090-53-6

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Product Name

Ibiglustat
Note

Research use only, not for human use.
Brief Description

An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
Description

An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access; exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice; shows favorable pharmacological properties and safety profile.Other Indication Phase 2 Clinical
Synonyms

Venglustat;Genz-682452;GZ452
Pathway

Others
Target

Other Targets
Recptor

glucosylceramide synthase
Research Area

Other Indications
Indication

Other Disease

CAS Number

1401090-53-6
Formula Weight

389.49
Molecular Formula

C20H24FN3O2S
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C
Chemical Name

(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate

1. Ashe KM, et al. Mol Med. 2015 Apr 30;21:389-99.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.

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