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Ibiglustat
CAS No. 1401090-53-6
Ibiglustat ( Venglustat;Genz-682452;GZ452 )
Catalog No. M11673 CAS No. 1401090-53-6
An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 72 | In Stock |
|
| 5MG | 147 | In Stock |
|
| 10MG | 266 | In Stock |
|
| 25MG | 469 | In Stock |
|
| 50MG | 680 | In Stock |
|
| 100MG | 954 | In Stock |
|
| 500MG | 1908 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIbiglustat
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NoteResearch use only, not for human use.
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Brief DescriptionAn orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
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DescriptionAn orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access; exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice; shows favorable pharmacological properties and safety profile.Other Indication Phase 2 Clinical
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SynonymsVenglustat;Genz-682452;GZ452
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PathwayOthers
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TargetOther Targets
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Recptorglucosylceramide synthase
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1401090-53-6
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Formula Weight389.49
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Molecular FormulaC20H24FN3O2S
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C
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Chemical Name(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ashe KM, et al. Mol Med. 2015 Apr 30;21:389-99.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.
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