Cart
sales@molnova.com
Ibiglustat
CAS No. 1401090-53-6
Ibiglustat ( Venglustat;Genz-682452;GZ452 )
Catalog No. M11673 CAS No. 1401090-53-6
An orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 72 | In Stock |
|
| 5MG | 147 | In Stock |
|
| 10MG | 266 | In Stock |
|
| 25MG | 469 | In Stock |
|
| 50MG | 680 | In Stock |
|
| 100MG | 954 | In Stock |
|
| 500MG | 1908 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameIbiglustat
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access.
-
DescriptionAn orally active, selective and potent Glucosylceramide synthase (GCS) inhibitor with central nervous system (CNS) access; exhibits significantly lower tissue levels of GL-3 and lyso-GL-3 and a delayed progression of a thermal nociceptive response in administered Fabry mice; shows favorable pharmacological properties and safety profile.Other Indication Phase 2 Clinical
-
SynonymsVenglustat;Genz-682452;GZ452
-
PathwayOthers
-
TargetOther Targets
-
Recptorglucosylceramide synthase
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number1401090-53-6
-
Formula Weight389.49
-
Molecular FormulaC20H24FN3O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESO=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C
-
Chemical Name(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ashe KM, et al. Mol Med. 2015 Apr 30;21:389-99.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.
2. Marshall J, et al. Mol Ther. 2016 Jun;24(6):1019-1029.
molnova catalog
related products
-
6-O-α-D-Glucopyranos...
Palatinose is a disaccharide having an α(1→6) linkage between D-glucose and D-fructose and is similar to sucrose in its physicochemical properties. It is produced from sucrose in some bacteria by the action of sucrose isomerase. In mammalian gut palatinose is hydrolyzed and absorbed much more slowly than sucrose.
-
Ethyl6-bromo-1H-indo...
Ethyl6-bromo-1H-indole-3-carboxylate is a marine derived natural products found in Pleroma menoui.
-
Mitoxantrone
Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication.
