IWP-L6 ( IWP-L6;PORCN Inhibitor III )

Catalog No. M17292 CAS No. 1427782-89-5

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Product Name

IWP-L6
Note

Research use only, not for human use.
Brief Description

IWP-L6 is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Description

IWP-L6, also known as PORCN Inhibitor III and Wnt Pathway Inhibitor XIX, is a potent inhibitor of PORCN (EC50 = 0.5 nM). Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and activity.
Synonyms

IWP-L6;PORCN Inhibitor III
Pathway

Others
Target

Other Targets
Recptor

Porcn
Research Area

Cancer
Indication

——

CAS Number

1427782-89-5
Formula Weight

472.58
Molecular Formula

C25H20N4O2S2
Purity

98%
Solubility

DMSO : 1.43 mg/mL 3.03 mM;
SMILES

O=C(CSc1nc2c(SCC2)c(=O)n1c1ccccc1)Nc1ncc(cc1)c1ccccc1
Chemical Name

N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

1. Wang X, et al. J Med Chem. 2013, 56(6), 2700-2704.

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