ISA-2011B

CAS No. 1395347-24-6

ISA-2011B ( —— )

Catalog No. M26721 CAS No. 1395347-24-6

ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 260 Get Quote
10MG 416 Get Quote
25MG 714 Get Quote
50MG 1017 Get Quote
100MG 1368 Get Quote
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Biological Information

  • Product Name
    ISA-2011B
  • Note
    Research use only, not for human use.
  • Brief Description
    ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.
  • Description
    ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.(In Vitro):ISA-2011B treatment abolished AR expression in the nucleus, without depleting the cytoplasmic AR . The proliferation rate of PC-3 cells after treatment with ISA-2011B at 10, 20, and 50 μM is obviously reduced to 58.77%, 48.65%, and 21.62% of vehicle-treated controls, respectively. ISA-2011B leads to a remarkable reduction in AR-V7 and CDK1 in both nucleus and cytoplasm of 22Rv1 cells. ISA-2011B shows the highest binding affinity to PIP5K1α, and to MAP/microtubule affinity-regulating kinase 1 and 4 (MARK1 and MARK4) across 460 kinases. ISA-2011B treatment inhibits PIP5K1α expression by 78.6% in PC-3 cells .(In Vivo):In xenograft mice, ISA-2011B disrupts protein stabilization of AR-V7 which is dependent on PIP5K1α, leading to suppression of invasive growth of AR-V7-high tumors. Overexpression of AR-V7 increases PIP5K1α, promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor ISA-2011B suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7. ISA-2011B obviously suppresses the growth of tumor cells in xenograft mice and is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways .
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    estrogen receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1395347-24-6
  • Formula Weight
    423.9
  • Molecular Formula
    C22H18ClN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@]12Cc3cc4OCOc4cc3[C@H](N1C(=O)CN(C)C2=O)c1c[nH]c2ccc(Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1..Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242.
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