ISA-2011B
CAS No. 1395347-24-6
ISA-2011B ( —— )
Catalog No. M26721 CAS No. 1395347-24-6
ISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 260 | Get Quote |
|
10MG | 416 | Get Quote |
|
25MG | 714 | Get Quote |
|
50MG | 1017 | Get Quote |
|
100MG | 1368 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameISA-2011B
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NoteResearch use only, not for human use.
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Brief DescriptionISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.
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DescriptionISA-2011B is an inhibitor of PIP5K1α and can be used in anticancer studies.(In Vitro):ISA-2011B treatment abolished AR expression in the nucleus, without depleting the cytoplasmic AR . The proliferation rate of PC-3 cells after treatment with ISA-2011B at 10, 20, and 50 μM is obviously reduced to 58.77%, 48.65%, and 21.62% of vehicle-treated controls, respectively. ISA-2011B leads to a remarkable reduction in AR-V7 and CDK1 in both nucleus and cytoplasm of 22Rv1 cells. ISA-2011B shows the highest binding affinity to PIP5K1α, and to MAP/microtubule affinity-regulating kinase 1 and 4 (MARK1 and MARK4) across 460 kinases. ISA-2011B treatment inhibits PIP5K1α expression by 78.6% in PC-3 cells .(In Vivo):In xenograft mice, ISA-2011B disrupts protein stabilization of AR-V7 which is dependent on PIP5K1α, leading to suppression of invasive growth of AR-V7-high tumors. Overexpression of AR-V7 increases PIP5K1α, promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor ISA-2011B suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7. ISA-2011B obviously suppresses the growth of tumor cells in xenograft mice and is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways .
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorestrogen receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1395347-24-6
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Formula Weight423.9
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Molecular FormulaC22H18ClN3O4
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Purity>98% (HPLC)
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Solubility——
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SMILES[H][C@@]12Cc3cc4OCOc4cc3[C@H](N1C(=O)CN(C)C2=O)c1c[nH]c2ccc(Cl)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1..Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242.
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