IPI-549 ( IPI549;IPI 549 )

Catalog No. M12582 CAS No. 1693758-51-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

IPI-549
Note

Research use only, not for human use.
Brief Description

IPI-549 (IPI549) is apotent, highly selective, orally active inhibitor of PI3Kγ with IC50 of 16 nM.
Description

IPI-549 (IPI549) is apotent, highly selective, orally active inhibitor of PI3Kγ with IC50 of 16 nM, displays >100-fold selectivity over other lipid and protein kinases (PI3Kα IC50=3.2 uM, PI3Kβ IC50=3.5 uM, PI3Kδ IC50>8.4 uM); demonstrates excellent PI3Kγ potency (IC50=1.2 nM) and selectivity against other Class I PI3K isoforms (>146-fold) in cellular phospho-AKT assays, dose dependently inhibits PI3Kγ dependent bone marrow-derived macrophage (BMDM) migration; demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo.Solid Tumors Phase 1 Clinical
Synonyms

IPI549;IPI 549
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1693758-51-8
Formula Weight

528.56
Molecular Formula

C30H24N8O2
Purity

>98% (HPLC)
Solubility

DMSO: 15 mg/mL
SMILES

O=C1N(C2=CC=CC=C2)C([C@@H](NC(C3=C(N=CC=C4)N4N=C3N)=O)C)=CC5=CC=CC(C#CC6=CN(C)N=C6)=C51
Chemical Name

Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-

1. Evans CA, et al. ACS Med Chem Lett. 2016 Jul 22;7(9):862-7.
2. De Henau O, et al. Nature. 2016 Nov 17;539(7629):443-447.

Calculator

molnova catalog