IPA-3
CAS No. 42521-82-4
IPA-3 ( IPA-3; IPA 3; IPA3 )
Catalog No. M18540 CAS No. 42521-82-4
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 35 | In Stock |
|
10MG | 55 | In Stock |
|
25MG | 106 | In Stock |
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50MG | 194 | In Stock |
|
100MG | 341 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameIPA-3
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NoteResearch use only, not for human use.
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Brief DescriptionIPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
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DescriptionIPA-3 is a potent and selective PAK1 inhibitor. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. IPA-3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA-3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF-κB. IPA-3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse xenograft assay demonstrated that IPA-3 treatment significantly reduced the tumor growth rate and decreased tumor volume, indicating that IPA-3 can suppress the in vivo tumor growth of HCC cells. Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior, suggesting that PAK1 is a potential therapeutic target in HCC.
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SynonymsIPA-3; IPA 3; IPA3
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PathwayOthers
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TargetOther Targets
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RecptorPAK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number42521-82-4
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Formula Weight350.45
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Molecular FormulaC20H14O2S2
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Purity98%
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SolubilityDMSO : ≥ 100 mg/mL 285.35 mM; H2O : < 0.1 mg/mL
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SMILESOC1=CC=C2C=CC=CC2=C1SSC1=C2C=CC=CC2=CC=C1O
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Chemical Name1,1'-disulfanediylbis(naphthalen-2-ol)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Deacon SW, et al. Chem Biol, 2008, 15(4), 322-331.
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