IPA-3

CAS No. 42521-82-4

IPA-3 ( IPA-3; IPA 3; IPA3 )

Catalog No. M18540 CAS No. 42521-82-4

IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 35 In Stock
10MG 55 In Stock
25MG 106 In Stock
50MG 194 In Stock
100MG 341 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    IPA-3
  • Note
    Research use only, not for human use.
  • Brief Description
    IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
  • Description
    IPA-3 is a potent and selective PAK1 inhibitor. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. IPA-3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA-3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF-κB. IPA-3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse xenograft assay demonstrated that IPA-3 treatment significantly reduced the tumor growth rate and decreased tumor volume, indicating that IPA-3 can suppress the in vivo tumor growth of HCC cells. Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior, suggesting that PAK1 is a potential therapeutic target in HCC.
  • Synonyms
    IPA-3; IPA 3; IPA3
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PAK1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    42521-82-4
  • Formula Weight
    350.45
  • Molecular Formula
    C20H14O2S2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 100 mg/mL 285.35 mM; H2O : < 0.1 mg/mL
  • SMILES
    OC1=CC=C2C=CC=CC2=C1SSC1=C2C=CC=CC2=CC=C1O
  • Chemical Name
    1,1'-disulfanediylbis(naphthalen-2-ol)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Deacon SW, et al. Chem Biol, 2008, 15(4), 322-331.
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