IP7e

CAS No. 500164-74-9

IP7e ( IP 7e;IP-7e;isoxazolo-pyridinone 7e )

Catalog No. M27887 CAS No. 500164-74-9

IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 356 Get Quote
10MG 530 Get Quote
25MG 851 Get Quote
50MG 1152 Get Quote
100MG 1557 Get Quote
500MG 3114 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    IP7e
  • Note
    Research use only, not for human use.
  • Brief Description
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.
  • Description
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.(In Vivo):IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE).
  • Synonyms
    IP 7e;IP-7e;isoxazolo-pyridinone 7e
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ACMSD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    500164-74-9
  • Formula Weight
    390.4
  • Molecular Formula
    C23H22N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759.
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