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IP7e

CAS No. 500164-74-9

IP7e ( IP 7e;IP-7e;isoxazolo-pyridinone 7e )

Catalog No. M27887 CAS No. 500164-74-9

IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    IP7e
  • Note
    Research use only, not for human use.
  • Brief Description
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.
  • Description
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.(In Vivo):IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE).
  • Synonyms
    IP 7e;IP-7e;isoxazolo-pyridinone 7e
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ACMSD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    500164-74-9
  • Formula Weight
    390.4
  • Molecular Formula
    C23H22N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759.
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