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Home - Products - Chromatin/Epigenetic - Histone Demethylase - IOX1

IOX1

CAS No. 5852-78-8

IOX1 ( IOX 1;IOX-1 )

Catalog No. M15148 CAS No. 5852-78-8

IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 55 In Stock
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25MG 178 In Stock
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Biological Information

  • Product Name
    IOX1
  • Note
    Research use only, not for human use.
  • Brief Description
    IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
  • Description
    IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7; IOX1 is less potent against BBOX1 (IC50=196 uM); chelates to Fe(II) in the active site of 2OG oxygenases; suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.
  • Synonyms
    IOX 1;IOX-1
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    KDM2A;KDM3A;KDM4C;KDM4E;KDM6B
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    5852-78-8
  • Formula Weight
    189.17
  • Molecular Formula
    C10H7NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 24 mg/mL
  • SMILES
    O=C(C1=C2C=CC=NC2=C(O)C=C1)O
  • Chemical Name
    5-Quinolinecarboxylic acid, 8-hydroxy-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schiller R, et al. ChemMedChem. 2014 Mar;9(3):566-71.
2. Hu Q, et al. Int J Mol Med. 2016 Jan;37(1):189-96.
3. Mettananda S, et al. Haematologica. 2017 Mar;102(3):e80-e84.
4. Hopkinson RJ, et al. Chem Sci. 2013 Aug 1;4(8):3110-3117.
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