INU-101( INU101 | INU 101 )

Catalog No. M12113 CAS No. 1513828-41-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

INU-101
Note

Research use only, not for human use.
Brief Description

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively.
Description

INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rats, and human 11β-HSD1, respectively; displays good selectivity for human 11β-HSD1 over 11β-HSD2 (IC50>10 uM); significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes (IC50=9.1 nM), enhances insulin sensitivity and lowers the fasting blood glucose level in KKAy mice, ob/ob mice and ZDF rats after oral administration, decreases the body weight and ameliorates an improved lipid profile in the diabetic mouse model.
In Vitro

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In Vivo

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Synonyms

INU101 | INU 101
Pathway

Metabolic Enzyme/Protease
Target

11β-HSD
Recptor

11β-HSD
Research Area

——
Indication

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CAS Number

1513828-41-5
Formula Weight

437.53
Molecular Formula

C21H28FN3O4S
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)N)NS(=O)(=O)C4=CC=CC=C4F
Chemical Name

(1S,3R,4S,5S,7S)-4-(2-((2-fluorophenyl)sulfonamido)-2-methylpropanamido)adamantane-1-carboxamide

1. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.

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