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INT-777
CAS No. 1199796-29-6
INT-777( —— )
Catalog No. M32967 CAS No. 1199796-29-6
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 211 | Get Quote |
|
| 5MG | 330 | Get Quote |
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| 10MG | 472 | Get Quote |
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| 25MG | 771 | Get Quote |
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| 50MG | 1067 | Get Quote |
|
| 100MG | 1404 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameINT-777
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NoteResearch use only, not for human use.
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Brief DescriptionINT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
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DescriptionINT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetGPCR19
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RecptorGPCR19
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Research Area——
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Indication——
Chemical Information
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CAS Number1199796-29-6
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Formula Weight450.65
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Molecular FormulaC27H46O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : ≥ 50 mg/mL (110.95 mM) DMSO : ≥ 31 mg/mL (68.79 mM)
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SMILES[H][C@@]12CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])[C@H](O)[C@H](CC)[C@]2([H])C[C@H](O)CC[C@]12C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.?
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