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INI-43

CAS No. 881046-01-1

INI-43 ( INI 43; INI43; INI-43 )

Catalog No. M27884 CAS No. 881046-01-1

INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    INI-43
  • Note
    Research use only, not for human use.
  • Brief Description
    INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF.
  • Description
    INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NF.
  • Synonyms
    INI 43; INI43; INI-43
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PLD1;PLD2;Dopamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    881046-01-1
  • Formula Weight
    385.5
  • Molecular Formula
    C22H23N7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(C)CCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc3ccccc3nc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Skafi N, et al. Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease. J Cell Physiol. 2019 Apr;234(4):4825-4839.
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