INE963

CAS No. 2640567-43-5

INE963 ( —— )

Catalog No. M28872 CAS No. 2640567-43-5

INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 123 Get Quote
10MG 192 Get Quote
25MG 392 Get Quote
50MG 579 Get Quote
100MG 824 Get Quote
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Biological Information

  • Product Name
    INE963
  • Note
    Research use only, not for human use.
  • Brief Description
    INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h.
  • Description
    INE963 demonstrates potent cellular activity against Pf 3D7 (EC50 = 6 nM) and achieves "artemisinin-like" kill kinetics in vitro with a parasite clearance time of <24 h. INE963 is also potent against P. falciparum and P. vivax clinical isolates from Brazil and Uganda with EC50’s ranging from 0.01 to 7.0 nM(In Vitro):INE963 is active against >15 drug-resistant Pf cell lines with EC50’s = 0.5–15 nM. The in vitro log parasite reduction ratio for INE963 is >8.0 at 10 × Pf 3D7 EC50 without a lag phase and a parasite clearance time (PCT99.9) of <24 h. The in vitro selectivity of INE963for Plasmodium vs human cells was exemplified by approximately 1000+ fold shifts against multiple human kinase biochemical assays.(In Vivo):Following four oral doses at 30 mg/kg of INE963, the frontrunner compounds tested showed significant parasitemia reduction (>99.9%) at day 5 compared to untreated control mice. In addition, the animals did not show any signs of recrudescence of parasite at day 60 post-treatment, indicating complete cure at these doses.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2640567-43-5
  • Formula Weight
    402.5
  • Molecular Formula
    C19H26N6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)c(cc1)nc(OC)c1-c1cnc2sc(N(CC3)CCC3(CN)O)nn12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Balasubramanian T, et al. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003 Oct 5;3:930-6.
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