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IMTPPE
CAS No. ——
IMTPPE( SID 3712502 )
Catalog No. M17020 CAS No. ——
IMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameIMTPPE
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NoteResearch use only, not for human use.
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Brief DescriptionIMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.
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DescriptionIMTPPE (SID 3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells; IMTPPE inhibited proliferation of AR-positive, but not AR-negative, prostate cancer cells in culture. IMTPPE inhibited the transcriptional activity of a mutant AR lacking the ligand-binding domain (LBD); IMTPPE inhibited the growth of 22Rv1 xenograft tumor, a model for enzalutamide-resistant prostate cancer.
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In Vitro——
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In Vivo——
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SynonymsSID 3712502
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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RecptorAndrogen Receptor (AR)
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight317.407
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Molecular FormulaC16H19N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Masoodi KZ, et al. Endocrinology. 2017 Oct 1;158(10):3152-3161.
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